Intravitreal Metformin Protects Against Choroidal Neovascularization and Light-Induced Retinal Degeneration.

ABSTRACT: Neovascular age-related macular degeneration (nAMD), a leading cause of blindness in older adults, presents a challenging pathophysiology involving choroidal neovascularization (CNV) and retinal degeneration. Current treatments relying on intravitreal (IVT) administration of anti-angiogenic agents are costly and of moderate effectiveness. Metformin, the common anti-diabetic drug, has been associated with decreased odds of developing AMD. Studies have shown that metformin can mitigate cellular aging, neoangiogenesis, and inflammation across multiple diseases. This preclinical study assessed metformin's impact on vessel growth using choroidal explants before exploring IVT metformin's effects on laser-induced CNV and light-induced retinal degeneration in C57BL/6J and BALB/cJ mice, respectivel

SUBMITTER: Xiao JF 

PROVIDER: S-EPMC11545389 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature