Elevated Platelet Aggregation in Patients with Ovarian Cancer: More than Just Increased Platelet Count.

ABSTRACT: Background: Patients with ovarian cancer have high platelet counts, which correlate with disease burden, incidence, and lethality of blood clots (thrombosis). We hypothesized that elevated aggregation is associated with both increased platelet number and altered behavior of platelets in patients with ovarian cancer. Methods: Healthy controls and patients with suspected or diagnosed ovarian cancer were evaluated for complete blood counts. To evaluate the effects of platelet count versus platelet behavior, equal platelet-rich plasma (PRP) volumes versus equal platelet numbers were used in platelet aggregation assays. Arachidonic acid, adenosine diphosphate, and collagen platelet agonists were used to induce aggregation. Volunteers were grouped into healthy controls (23), benign

SUBMITTER: Isingizwe ZR 

PROVIDER: S-EPMC11545395 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature