Real-World and Patient-Reported Outcomes of Dupilumab and Other Biological Drugs for Chronic Obstructive Pulmonary Disease-A Systematic Review.

ABSTRACT:

Background

Over the last few decades, the efficacy of biological therapies for COPD has been evaluated by different randomized controlled trials (RCTs). Still, the evaluation of real-world data and patient-reported outcome measures (PROMs) have not been performed in this field before. In the current work, we present a systematic literature review of the real-world data and PROMs of biological treatments for COPD.

Methods

Three large databases (MEDLINE/PubMed, Scopus, and ScienceDirect) were utilized for the systematic literature review. Clinical studies (RCT, cohorts, case series/reports) assessing patients with COPD treated by any biological therapy were included.

Results

The review resulted in twelve eligible studies (nine randomized controlled trials and three "rea

SUBMITTER: Freund O 

PROVIDER: S-EPMC11545442 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature