Deciphering CD59: Unveiling Its Role in Immune Microenvironment and Prognostic Significance.

ABSTRACT:

Background

CD59, a GPI-anchored membrane protein, protects cancer cells from complement-dependent cytotoxicity (CDC) by inhibiting the formation of the membrane attack complex (MAC). It has been demonstrated to be overexpressed in most solid tumors, where it facilitates tumor cell escape from complement surveillance. The role of CD59 in cancer growth and interactions between CD59 and immune cells that modulate immune evasion has not been well explored.

Methods

Using cancer patient database from The Cancer Genome Atlas (TCGA) and other public databases, we analyzed CD59 expression, its prognostic significance, and its association with immune cell infiltration in the tumor microenvironment, identifying associated genomic and functional networks and validating findings with inv

SUBMITTER: Patel B 

PROVIDER: S-EPMC11545456 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature