Overexpression of CDCA8 predicts poor prognosis and drug insensitivity in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) accounts for the highest proportion of lung cancers; however, specific biomarkers are lacking for diagnosis, treatment, and prognostic assessment. Cell division cycle-associated 8 (CDCA8) is a cell cycle regulator with elevated expression in various cancers. However, the association between CDCA8 expression and LUAD prognosis remains unclear.

Methods

The association between CDCA8 and LUAD prognosis was evaluated based on the The Cancer Genome Atlas (TCGA) dataset, and CDCA8 related functions were determined using gene enrichment and gene ontology analyses. We also analyzed the association between CDCA8 expression and immune cell infiltration. Immunohistochemistry was used to determine the differential expression of CDCA8 in tumors and co

SUBMITTER: Gu H 

PROVIDER: S-EPMC11545569 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature