Mood instability metrics to stratify individuals and measure outcomes in bipolar disorder.

ABSTRACT: Clinical care for bipolar disorder (BD) has a narrow focus on prevention and remission of episodes with pre/post treatment reductions in symptom severity as the 'gold standard' for outcomes in clinical trials and measurement-based care strategies. The study aim was to provide a innovative method for measuring outcomes in BD that has clinical utility and can stratify individuals with BD based on mood instability. Participants were 603 with a BD (n=385), other or non-affective disorder (n=71), or no psychiatric history (n=147) enrolled in an longitudinal cohort for at least 10 years that collects patient reported outcomes measures (PROMs) assessing depression, (hypo)mania, anxiety, and functioning every two months. Mood instability was calculated as the intraindividual standard deviation (s.

SUBMITTER: Sperry SH 

PROVIDER: S-EPMC11545575 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature