MiRNA Profiling of Areca Nut-Induced Carcinogenesis in Head and Neck Cancer.

ABSTRACT:

Background

While miRNAs are increasingly recognized for their role in tumorigenesis, their involvement in head and neck cancer (HNC) remains insufficiently explored. Additionally, the carcinogenic mechanisms of areca nut, a major habitual carcinogen in Southeast Asia, are not well understood.

Methods and results

This study adopts a systematic approach to identify miRNA profiles associated with areca nut-induced HNC. Using miRNA microarray analysis, we identified 292 miRNAs dysregulated in areca nut-treated HNC cells, with 136 upregulated and 156 downregulated. Bioinformatic analysis of the TCGA-HNSC dataset uncovered a set of 692 miRNAs relevant to HNC development, comprising 449 overexpressed and 243 underexpressed in tumor tissues. Integrating these datasets, we defined a

SUBMITTER: Huang HH 

PROVIDER: S-EPMC11545612 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature