Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma.

ABSTRACT: Background/Objectives: Warburg's metabolic paradox illustrates that malignant cells require both glucose and oxygen to survive, even after converting glucose into lactate. It remains unclear whether sparing glucose from oxidation intersects with TCA cycle continuity and if this confers any metabolic advantage in proliferating cancers. This study seeks to understand the mechanistic basis of Warburg's paradox and its overall implications for lymphomagenesis. Methods: Using metabolomics, we first examined the metabolomic profiles, glucose, and glutamine carbon labeling patterns in the metabolism during the cell cycle. We then investigated proliferation-specific metabolic features of malignant and nonmalignant cells. Finally, through bioinformatics and the identification of appro

SUBMITTER: Ravi D 

PROVIDER: S-EPMC11545614 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature