Su(H) Modulates Enhancer Transcriptional Bursting in Prelude to Gastrulation.

ABSTRACT: Transcriptional regulation, orchestrated by the interplay between transcription factors (TFs) and enhancers, governs gene expression dynamics crucial for cellular processes. While gross qualitative fluctuations in transcription factor-dependent gene expression patterning have a long history of characterization, the roles of these factors in the nuclei retaining expression in the presence or absence of these factors are now observable using modern techniques. Our study investigates the impact of Suppressor of Hairless (Su(H)), a broadly expressed transcription factor, on enhancer-driven transcriptional modulation using Drosophila early embryos as a model system. Building upon previous findings, we employ super-resolution microscopy to dissect Su(H)'s influence on sog-Distal (<

SUBMITTER: Fenelon KD 

PROVIDER: S-EPMC11545809 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature