Factors associated with long-term cardiac dysfunction in neonatal lupus.

ABSTRACT:

Objectives

Cardiac manifestations of neonatal lupus (NL) have been associated with significant morbidity and mortality; however, there is minimal information on long-term outcomes of affected individuals. This study was initiated to evaluate the presence of and the risk factors associated with cardiac dysfunction in NL after birth in multiple age groups to improve counselling, to further understand pathogenesis and to provide potential preventative strategies.

Methods

Echocardiogram reports were evaluated in 239 individuals with cardiac NL: 143 from age 0-1 year, 176 from age >1-17 years and 64 from age >17 years. Logistic regression analyses evaluated associations of cardiac dysfunction at each age group with demographic, fetal and postnatal factors, using imputation to add

SUBMITTER: Saxena A 

PROVIDER: S-EPMC11545888 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature