H-NMR metabolomics identifies three distinct metabolic profiles differentially associated with cardiometabolic risk in patients with obesity in the [e-mail] cohort.

ABSTRACT:

Background

Obesity is a complex, diverse and multifactorial disease that has become a major public health concern in the last decades. The current classification systems relies on anthropometric measurements, such as BMI, that are unable to capture the physiopathological diversity of this disease. The aim of this study was to redefine the classification of obesity based on the different H-NMR metabolomics profiles found in individuals with obesity to better assess the risk of future development of cardiometabolic disease.

Materials and methods

Serum samples of a subset of the [e-mail] cohort consisting of 1387 individuals with obesity were analyzed by H-NMR. A K-means algorithm was deployed to define different H-NMR metabolomics-based clusters. Then, the association of thes

SUBMITTER: Ozcariz E 

PROVIDER: S-EPMC11545907 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature