Enhanced ROS Production and Mitochondrial Metabolic Shifts in CD4⁺ T Cells of an Autoimmune Uveitis Model.

ABSTRACT: Equine recurrent uveitis (ERU) is a spontaneously occurring autoimmune disease and one of the leading causes of blindness in horses worldwide. Its similarities to autoimmune-mediated uveitis in humans make it a unique spontaneous animal model for this disease. Although many aspects of ERU pathogenesis have been elucidated, it remains not fully understood and requires further research. CD4⁺ T cells have been a particular focus of research. In a previous study, we showed metabolic alterations in CD4⁺ T cells from ERU cases, including an increased basal oxygen consumption rate (OCR) and elevated compensatory glycolysis. To further investigate the underlying reasons for and consequences of these metabolic changes, we quantified reactive oxygen species (ROS) production in

SUBMITTER: Soth R 

PROVIDER: S-EPMC11545935 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature