A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stages.

ABSTRACT:

Background

The long-term effectiveness of immunotherapies against Multiple Myeloma (MM) remains elusive, demonstrated by the inevitable relapse in patients. This underscores the urgent need for an in-depth analysis of the MM tumor-immune microenvironment (TME). Hereto, a representative immunocompetent MM mouse model can offer a valuable approach to study the dynamic changes within the MM-TME and to uncover potential resistance mechanisms hampering effective and durable therapeutic strategies in MM.

Methods

We generated a comprehensive single-cell RNA-sequencing atlas of the MM-TME in bone marrow and spleen encompassing different stages of disease, using the immunocompetent 5T33MM mouse model. Through comparative analysis, we correlated our murine dataset with the pathogenesi

SUBMITTER: Verheye E 

PROVIDER: S-EPMC11546219 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature