A new multi-epitope DNA vaccine against Helicobacter Pylori infection in a BALB/c mouse model.

ABSTRACT:

Background

Helicobacter Pylori (H. Pylori) is a pathogen that may invade the human stomach. This bacterial strain is now causing widespread concern and considerable health issues worldwide. In contrast to antibiotic treatment, which may lead to drug resistance, vaccination therapy is emerging as a possible immunotherapy option for H. Pylori. DNA vaccines are a potential option to traditional vaccines among vaccine research methods. Furthermore, the multiepitope DNA vaccination may induce a broader immune response to suppress H. Pylori infection.

Methods

Four target antigenic proteins (outer membrane beta-barrel, outer membrane beta, HofA, and hcp beta-lactamase-like protein) were used to identify epitopes. The best B and T cell epitopes were selec

SUBMITTER: Azami Z 

PROVIDER: S-EPMC11546231 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature