AMPA and NMDA Receptors in Hippocampus of Rats with Fluoride-Induced Cognitive Decline.

ABSTRACT: This experimental study was performed to evaluate the alterations in the expression of a few subunits composing glutamate AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) receptors in the hippocampal cells of Wistar rats in response to long-term fluoride (F^-) exposure. The animals were given water with background 0.4 (control), 5, 20, and 50 ppm F^- (as NaF) for 12 months. The cognitive capacities of rats were examined by novel object recognition (NOR), Y-maze test, and Morris water maze tests. RT-qPCR and Western blotting techniques were used to evaluate the expression of different AMPA and NMDA subunits at transcriptional and translational levels, respectively. Long-term F^- poisoning disturbed the formation of hip

SUBMITTER: Nadei OV 

PROVIDER: S-EPMC11546234 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature