ALKBH5 Protects Against Hepatic Ischemia-Reperfusion Injury by Regulating YTHDF1-Mediated YAP Expression.

ABSTRACT: Ischemia/reperfusion (I/R) injury with severe cell death is a major complication involved in liver transplantation and resection. The identification of key regulators improving hepatocyte activity may provide potential strategies to clinically resolve I/R-induced injury. N⁶-methyladenosine (m⁶A) RNA modification is essential for tissue homeostasis and pathogenesis. However, the potential involvement of m⁶A in the regulation of hepatocyte activity and liver injury has not been fully explored. In the present study, we found that hepatocyte AlkB homolog H5 (ALKBH5) levels were decreased both in vivo and in vitro I/R models. Hepatocyte-specific ALKBH5 overexpression effectively attenuated I/R-induced liver necrosis and improved cell proliferation in mice. Mecha

SUBMITTER: Wang P 

PROVIDER: S-EPMC11546256 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature