ANXA4 restricts HBV replication by inhibiting autophagic degradation of MCM2 in chronic hepatitis B.

ABSTRACT:

Background

Hepatitis B virus (HBV) is an enveloped DNA virus that causes chronic hepatitis B (CHB) infection. Annexin, a Ca²⁺-activated protein, is widely expressed in various organs and tissues and has potential utility in disease diagnosis and treatment. However, the relationship between the annexin family and CHB remains unclear.

Methods

Clinical samples from hepatitis patients and donors or healthy individuals were collected. Transcriptome sequencing in CHB liver tissues and HBV-infected cells were performed. HepG2.2.15 cells with the full-length HBV genome and HBV-infected HepG2-NTCP cell models were established. HBV-infected mouse model was constructed and adeno-associated virus was utilized.

Results

ANXA4 expression was elevated during CHB infection.

SUBMITTER: Yang L 

PROVIDER: S-EPMC11546334 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature