Association analysis of gut microbiota with LDL-C metabolism and microbial pathogenicity in colorectal cancer patients.

ABSTRACT:

Background

Colorectal cancer (CRC) is the most common gastrointestinal malignancy worldwide, with obesity-induced lipid metabolism disorders playing a crucial role in its progression. A complex connection exists between gut microbiota and the development of intestinal tumors through the microbiota metabolite pathway. Metabolic disorders frequently alter the gut microbiome, impairing immune and cellular functions and hastening cancer progression.

Methods

This study thoroughly examined the gut microbiota through 16S rRNA sequencing of fecal samples from 181 CRC patients, integrating preoperative Low-density lipoprotein cholesterol (LDL-C) levels and RNA sequencing data. The study includes a comparison of microbial diversity, differential microbiological analysis, exploration o

SUBMITTER: Qin M 

PROVIDER: S-EPMC11546423 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature