A Systems Biology Approach Towards a Comprehensive Understanding of Ferroptosis.

ABSTRACT: Ferroptosis is a regulated cell death process characterized by iron ion catalysis and reactive oxygen species, leading to lipid peroxidation. This mechanism plays a crucial role in age-related diseases, including cancer and cardiovascular and neurological disorders. To better mimic iron-induced cell death, predict the effects of various elements, and identify drugs capable of regulating ferroptosis, it is essential to develop precise models of this process. Such drugs can be tested on cellular models. Systems biology offers a powerful approach to studying biological processes through modeling, which involves accumulating and analyzing comprehensive research data. Once a model is created, it allows for examining the system's response to various stimuli. Our goal is to develop a modular fram

SUBMITTER: Arbatskiy M 

PROVIDER: S-EPMC11546516 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature