A causal association between chemokines and the risk of lung cancer: a univariate and multivariate mendelian randomization study.

ABSTRACT:

Background

Observational studies and experimental evidence have shown that chemokines play important roles in lung cancer development, progression, and treatment. However, few studies have examined the causal association between them.

Methods

Summary data of chemokines and lung cancer were obtained from genome-wide association studies. Mendelian randomization (MR) analyses were performed by five methods, Inverse variance weighted (IVW), Weighted median estimation, MR-Egger, Simple mode and Weighted, with IVW as the primary analysis method. Sensitivity analysis was used to assess the reliability of the MR results. Multivariate Mendelian randomization studies were used to infer whether causality was influenced by potential mediators. The expression levels of CCL21 were analyze

SUBMITTER: Wang M 

PROVIDER: S-EPMC11546554 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature