The impact of inter-cycle treatment delays on overall survival in patients with advanced-stage ovarian cancer.

ABSTRACT:

Introduction

Chemotherapy forms the cornerstone of systemic treatment for advanced ovarian cancer, extending overall survival; however, drug-related toxicity can lead to treatment delays, potentially diminishing treatment efficacy. This study evaluated the impact of treatment delays on all-cause mortality of patients with ovarian cancer, to better inform decisions on patient management.

Methods

This retrospective, population-based cohort study included 1517 women with advanced-stage ovarian cancer, receiving first-line adjuvant or neoadjuvant chemotherapy in 2014 and 2015. The frequency of inter-cycle delays >7 days was calculated using drug administration dates. Kaplan-Meier estimates were used to compare 2-year overall survival (OS) between patients who were delayed and th

SUBMITTER: Steventon L 

PROVIDER: S-EPMC11546639 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature