Outcomes in older adults with metastatic esophageal and gastric carcinoma treated with palliative chemotherapy.

ABSTRACT:

Background

The incidence of esophageal and gastric carcinoma (GEC) in elderly patients is increasing, yet patients ≥75 years have historically been underrepresented in clinical trials. We sought to investigate palliative chemotherapy administration patterns and survival outcomes in older adults.

Materials and methods

A retrospective analysis identified patients aged 65-74 (young-old) and ≥75 years (older-old) diagnosed with advanced GEC. Patient and tumor characteristics were recorded, with descriptive analysis, time-to-event data analysis using Kaplan-Meier curves and multivariate Cox proportional hazards regression analysis performed.

Results

One hundred and ninety-eight "young-old" and 109 'older-old' patients were identified. Patient characteristics were similar b

SUBMITTER: Wang X 

PROVIDER: S-EPMC11546644 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature