Systematic Review on Working Mechanisms of Signaling Pathways in Fibrosis During Shockwave Therapy.

ABSTRACT: Fibrosis is characterized by scarring and hardening of tissues and organs. It can affect every organ system, and so could result in organ failure due to the accumulation of extracellular matrix proteins. Previous studies suggest that mechanical forces (such as shockwave therapy, SWT) initiate a process of mechanotransduction and thus could regulate fibrosis. Nevertheless, it is largely unexamined which pathways are exactly involved in the application of SWT and can regulate fibrosis. The present article seeks to elucidate the underlying effect of SWT on fibrosis. Evidence shows that SWT activates macrophage activity, fibroblast activity, collagen amount and orientation and apoptosis, which ultimately lead to an adaptation of inflammation, proliferation, angiogenesis and apoptosis. The incl

SUBMITTER: Demuynck L 

PROVIDER: S-EPMC11546838 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature