The Glutamine Synthetases Are Required for Sensory Hair Cell Formation and Auditory Function in Zebrafish.

ABSTRACT: The development of sensory hair cells (HCs) is closely linked to hearing loss. There are still many unidentified genes that may play a crucial role in HC development and function. Glutamine synthetase, Glul, is expressed in sensory hair cells and auditory organs. However, the role of the Glul gene family in the auditory system remains largely unexplored. This study aims to investigate the function of the Glul gene family in the auditory system. The expression patterns of the glul gene family were examined via in situ hybridization in zebrafish embryos. It was revealed that the expression of glula occurred in the otic vesicle, while glulb was expressed in the neuromast. In contrast, glulc did not exhibit any discernible signal. glula loss of

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11546858 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature