Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data.

ABSTRACT:

Objectives

Experimental and genetic studies suggest that fibroblast growth factor 21 (FGF21) modulates macronutrient and alcohol preferences, but evidence of such regulation in humans remains scarce. To address this gap in translation, we aimed to map the relationships between plasma FGF21 levels, FGF21 genetic variation and habitual macronutrient intake in a large human population.

Methods

We fine-mapped and performed colocalization of the FGF21 genetic region in GWAS summary statistics of plasma FGF21 levels and macronutrient intake. UK Biobank data were used to investigate the associations between FGF21 genetic variants, plasma FGF21 protein levels, and macronutrient intake (including alcohol) assessed with repeated 24-hour recalls. One- and two-sample mendelian randomiza

SUBMITTER: Ramne S 

PROVIDER: S-EPMC11546929 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature