2-Bromopalmitate-Induced Intestinal Flora Changes and Testicular Dysfunction in Mice.

ABSTRACT: 2-Bromopalmitate (2-BP) is a palmitoylation inhibitor that can prevent the binding of palmitic acid to proteins, thereby exhibiting significant effects in promoting inflammation and regulating the immune system. However, limited research has been conducted regarding the direct effects of 2-BP on the animal organism. Therefore, we probed mice injected with 2-BP for altered expression of inflammatory genes, with a focus on demonstrating changes in the intestinal flora as well as damage to the reproductive system. Our findings indicate that 2-BP can induce substantial inflammatory responses in visceral organs and cause testicular dysfunction. The key changes in the gut microbiota were characterized by an abundance of Firmicutes, Clostridiales, Rikenellaceae_RC9_gut_group,

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11547043 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature