An Integrative Migraine Polygenic Risk Score Is Associated with Age at Onset But Not Chronification.

ABSTRACT: Background/Objective: Genome-wide association studies (GWASs) demonstrate a complex genetic landscape for migraine risk. Migraine polygenic risk scores (PRSs) developed from GWAS data may have utility for predicting disease course. We analyzed the strength of association between an integrative migraine PRS and age at onset and chronification. Methods: In this retrospective clinical/genetic case-control study, PGS004799 was calculated for adults with European ancestry from two real-world community cohorts. In the DodoNA cohort, 1653 treated, deeply phenotyped migraine cases, diagnosed using International Classification of Headache Disorders 3rd edition criteria, were followed for a mean (range) of 2.3 (1-10) years and compared to 3460 controls (without migraine diagnosis). In

SUBMITTER: Chase BA 

PROVIDER: S-EPMC11547092 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature