Loss of DNA Polymerase β Delays Atherosclerosis in <i>ApoE</i>^-/- Mice Due to Inhibition of Vascular Smooth Muscle Cell Migration.

ABSTRACT: Atherosclerosis (AS) is an inflammatory disease characterized by arterial inflammation. One important trigger for AS development is the excessive migration of vascular smooth muscle cells (VSMCs); however, the mechanism underlying this phenomenon remains unclear. Therefore, we investigated the role of DNA polymerase β (Pol β), a crucial enzyme involved in base excision repair, VSMC migration, and subsequent AS development. In this study, we revealed a significant increase in Pol β content within AS plaques in ApoE^-/-Pol β^+/+ mice. In vitro experiments demonstrated a significant decrease in hCASMC viability and migration ability upon Pol β knockdown, whereas the subsequent recovery of Pol β expression reversed this effect. Moreover, our investigations rev

SUBMITTER: Zhao L 

PROVIDER: S-EPMC11547094 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature