Transcriptome Sequencing-Based Screening of Key Melatonin-Related Genes in Ischemic Stroke.

ABSTRACT: Ischemic stroke (IS) is a complex syndrome of neurological deficits due to stenosis or occlusion of the carotid and vertebral arteries for which there is still no effective treatment. Melatonin, a hormone secreted by the pineal gland, has multiple biological effects, such as antioxidant and anti-inflammatory properties, circadian rhythm regulation, and tissue regeneration, demonstrating potential applications in the treatment of IS. The aim of this study was to investigate key melatonin-regulated genes associated with IS using transcriptome sequencing and bioinformatics analyses and to explore their potential mechanisms of action in the disease process. We obtained gene expression data related to ischemic stroke (IS) from the Gene Expression Omnibus (GEO) database and identified candidate

SUBMITTER: Li T 

PROVIDER: S-EPMC11547107 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature