Inhibitory Effect of Alnustone on Survival and Lung Metastasis of Colorectal Cancer Cells.

ABSTRACT:

Background/objectives

Alnustone (Aln) is an effective compound of Alpinia katsumadae Hayata. Aln possesses various pharmacological activities such as antibacterial, anti-inflammatory, and anti-cancer effects. However, the inhibitory effect of Aln on colorectal cancer (CRC) has not yet been identified. Thus, research was conducted to clarify whether Aln can suppress the proliferative and metastatic ability of CRC cells.

Methods

A cell viability assay was performed to confirm the decrease in CRC cell viability following Aln treatment. Flow cytometry was carried out to evaluate the effects of Aln on cell cycle arrest, autophagy, and apoptosis in CRC cells. In addition, a lung metastasis animal model was used to check the inhibitory effect of Aln on the metastasis of CRC

SUBMITTER: Park SY 

PROVIDER: S-EPMC11547205 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature