Circulating Phylloquinone and the Risk of Four Female-Specific Cancers: A Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies have linked vitamin K and cancer, but the causality of this association remains unknown. This Mendelian randomization (MR) study aims to investigate the association between circulating phylloquinone (vitamin K₁) levels and four female-specific cancers.

Methods

We used four single-nucleotide polymorphisms (SNPs) to instrument phylloquinone, with the reported F-statistic 16.00-28.44 for all variants. SNP-outcome associations were obtained from consortia meta-analyses, UK Biobank, and the FinnGen database (up to 145,257/419,675, 27,446/362,324, 15,181/591,477, and 2211/320,454 cases/controls for breast, ovarian, endometrial, and cervical cancer, respectively). Analyses were conducted using five complementary MR methods including pleio

SUBMITTER: Yalew M 

PROVIDER: S-EPMC11547380 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature