Synthesis and Docking Studies of Novel Spiro[5,8-methanoquinazoline-2,3'-indoline]-2',4-dione Derivatives.

ABSTRACT: In this study, a set of spiro[5,8-methanoquinazoline-2,3'-indoline]-2',4-dione derivatives 3a-p were synthesized starting from unsubstituted and N-methyl-substituted diendo- and diexo-2-aminonorbornene carboxamides, as well as various substituted isatins. The typical method involves a condensation reaction of alicyclic aminocarboxamide and isatin in the presence of a catalyst, using a solvent and an acceptable temperature. We developed a cost-effective and ecologically benign high-speed ball milling (HSBM), microwave irradiation (MW), and continuous flow (CF) technique to synthesize spiroquinazolinone molecule 3a. The structures of the synthesized compounds 3a-p were determined using 1D and 2D NMR spectroscopies. Furthermore, docking

SUBMITTER: Farago T 

PROVIDER: S-EPMC11547464 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature