Administration Route Differentiation of Altrenogest via the Metabolomic LC-HRMS Analysis of Equine Urine.

ABSTRACT: Altrenogest, also known as allyltrenbolone, is a synthetic form of progesterone used therapeutically to suppress unwanted symptoms of estrus in female horses. Altrenogest affects the system by decreasing levels of endogenous gonadotrophin and luteinizing and follicle-stimulating hormones, which in turn decreases estrogen and mimics the increase of progesterone production. This results in more manageable mares for training and competition alongside male horses while improving the workplace safety of riders and handlers. However, when altrenogest is administered, prohibited steroid impurities such as trendione, trenbolone, and epitrenbolone can be detected. It has been assumed that greater concentrations of these steroid impurities are present in injectable preparations and, therefore, pose

SUBMITTER: Elbourne M 

PROVIDER: S-EPMC11547534 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature