Systematic Review and Meta-Analysis on the Association Between Daily Niacin Intake and Glaucoma.

ABSTRACT:

Background

Glaucoma is a progressive optic neuropathy, characterised by a complex pathophysiology, with mitochondrial dysfunction playing a significant role in the cellular damage and apoptosis of ganglion cells. Niacin is a precursor to several molecules acting as coenzymes in the mitochondrial production of ATP, in DNA repair and in the reduction of reactive oxygen species. The objective of this systematic review is to assess the impact of daily niacin intake on glaucoma.

Methods

Case-control and cohort studies regarding niacin and glaucoma, indexed in PubMed, Web of Science, Cochrane and Scopus, were included. Other study methodologies, studies regarding niacin in other ocular disease or other nutrients in glaucoma were excluded. Bias was assessed using the Newcastle-Otta

SUBMITTER: Nicola CA 

PROVIDER: S-EPMC11547537 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature