S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review.

ABSTRACT:

Background/objectives

S-adenosylmethionine (SAMe) is a natural compound implicated in the treatment of liver dysfunction. In this systematic review, our objective was to determine the efficacy, safety, and optimal dose of SAMe in liver diseases.

Methods

Using the PRISMA methodology, we searched PubMed, CINAHL, and Web of Science using key MeSH search terms. For title/abstract screening, full-text review, and data extraction, two independent researchers reviewed articles, and a third researcher resolved conflicts. Data extraction also included a quality assessment of included articles.

Results

Of the 1881 non-duplicated studies, 15 articles focusing on SAMe use in the liver were included. All included studies (n = 15) scored a 4 or 5 out of 5 points on the quali

SUBMITTER: Baden KER 

PROVIDER: S-EPMC11547595 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature