Alleviation of Immobilization Stress or Fecal Microbiota-Induced Insomnia and Depression-like Behaviors in Mice by <i>Lactobacillus plantarum</i> and Its Supplement.

ABSTRACT: Insomnia (sleeplessness) is a potential symptom of stress-induced depression/anxiety (DA), which induces TNF-α expression. Therefore, this study aimed to examine the effect of Lactobacillus (Lactiplantibacillus) plantarum P72, isolated as a strain suppressing lipopolysaccharide-induced expression of TNF-α in Caco2 cells, on DA and insomnia in immobilization stress (IS)- or cultured fecal microbiota (cFM)-treated mice. Oral administration of live or heat-killed P72 (hP72) reduced IS- or cFM-induced DA-like behaviors. They also reduced sleep latency time (SLT) and enhanced sleep duration (SLD). Additionally, P72 upregulated γ-aminobutyric acid (GABA), GABA_A receptor α1, serotonin, and 5-HT_1A receptor expression, which were downregulated by IS or cFM

SUBMITTER: Lee DY 

PROVIDER: S-EPMC11547846 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature