Synergistic Combination of Quercetin and Mafosfamide in Treatment of Bladder Cancer Cells.

ABSTRACT: Bladder cancer, which has a rising incidence, is the 10th most common cancer. The transitional cell carcinoma histotype is aggressive and often current therapies are ineffective. We investigated the anti-proliferative effect of quercetin, a natural flavonoid, in combination with the alkylating agent mafosfamide (MFA) on two human bladder cancer cell lines, namely RT112 and J82, representing the progression from low-grade to high-grade tumors, respectively. In both cell types, the combined treatment led to a synergic reduction in cell viability confirmed by a combination index of less than one, though different biological responses were noted. In J82 cells, MFA alone and, to a lesser extent, with quercetin caused cell cycle arrest in the G2/M phase, but only the combined treatment triggered

SUBMITTER: Spagnuolo C 

PROVIDER: S-EPMC11547860 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature