Network Localization of State and Trait of Auditory Verbal Hallucinations in Schizophrenia.

ABSTRACT:

Background and hypothesis

Neuroimaging studies investigating the neural substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed results, which may be reconciled by network localization. We sought to examine whether AVH-state and AVH-trait brain alterations in schizophrenia localize to common or distinct networks.

Study design

We initially identified AVH-state and AVH-trait brain alterations in schizophrenia reported in 48 previous studies. By integrating these affected brain locations with large-scale discovery and validation resting-state functional magnetic resonance imaging datasets, we then leveraged novel functional connectivity network mapping to construct AVH-state and AVH-trait dysfunctional networks.

Study results

The neuroanato

SUBMITTER: Mo F 

PROVIDER: S-EPMC11548935 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature