Severe hypophosphatemia induced by excessive production of FGF23 in acute hepatitis: from bedside to bench.

ABSTRACT:

Background

Although hepatic production of FGF23 has been suggested in chronic settings, there are no data indicating hypophosphatemia resulting from acute hepatic FGF23 production. Based on two clinical observations of profound hypophosphatemia in the setting of acute hepatitis, our study investigates the hypothesis of acute FGF23 liver expression.

Methods

Retrospective analyses were conducted to estimate FGF23 liver expression both qualitatively (in situ hybridization) and quantitatively (relative FGF23 gene expression and protein production) on histological specimens of human and murine acute hepatitis livers, compared with controls of hepatic fibrosis or healthy liver.

Results

The index clinical case involves acute alcoholic hepatitis complicated by profound

SUBMITTER: Hamroun A 

PROVIDER: S-EPMC11548962 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature