DNA methylation is associated with hair trace elements in female adolescents from two vulnerable populations in the Colombian Caribbean.

ABSTRACT: Exposure to trace elements (TEs) influences DNA methylation patterns, which may be associated with disease development. Vulnerable populations, such as adolescents undergoing maturity, are susceptible to the effects of TE exposure. The aim of this study was to analyze the association of hair TE concentration with DNA methylation in a sample from female adolescents living in two communities in the Colombian Caribbean coast. Hair and blood samples were obtained from 45 females, between 13 and 16 years of age. Seventeen TEs were quantified in hair samples. DNA methylation was measured in leukocytes using the Infinium MethylationEPIC BeadChip. Linear models were employed to identify differentially methylated positions (DMPs) adjusting for age, body mass index, mother's education, and cell type

SUBMITTER: Manjarres-Suarez A 

PROVIDER: S-EPMC11548963 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature