Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study.

ABSTRACT:

Background

The biological mechanisms leading some tobacco-exposed individuals to develop early-stage chronic obstructive pulmonary disease (COPD) are poorly understood. This knowledge gap hampers development of disease-modifying agents for this prevalent condition.

Objectives

Accordingly, with National Heart, Lung and Blood Institute support, we initiated the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) Study of Early COPD Progression (SOURCE), a multicenter observational cohort study of younger individuals with a history of cigarette smoking and thus at-risk for, or with, early-stage COPD. Our overall objectives are to identify those who will develop COPD earlier in life, characterize them thoroughly, and by contrasting them to those not develo

SUBMITTER: Curtis JL 

PROVIDER: S-EPMC11548966 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature