Predicting 'pain genes': multi-modal data integration using probabilistic classifiers and interaction networks.

ABSTRACT:

Motivation

Accurate identification of pain-related genes remains challenging due to the complex nature of pain pathophysiology and the subjective nature of pain reporting in humans. Here, we use machine learning to identify possible 'pain genes'. Labelling was based on a gold-standard list with validated involvement across pain conditions, and was trained on a selection of -omics, protein-protein interaction network features, and biological function readouts for each gene.

Results

The top-performing model was selected to predict a 'pain score' per gene. The top-ranked genes were then validated against pain-related human SNPs. Functional analysis revealed JAK2/STAT3 signal, ErbB, and Rap1 signalling pathways as promising targets for further exploration, while network topologi

SUBMITTER: Zhao N 

PROVIDER: S-EPMC11549022 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature