Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder.

ABSTRACT: Classical metabolomic and new metabolic network methods were used to study the developmental features of autism spectrum disorder (ASD) in newborns (n = 205) and 5-year-old children (n = 53). Eighty percent of the metabolic impact in ASD was caused by 14 shared biochemical pathways that led to decreased anti-inflammatory and antioxidant defenses, and to increased physiologic stress molecules like lactate, glycerol, cholesterol, and ceramides. CIRCOS plots and a new metabolic network parameter, V ° _net, revealed differences in both the kind and degree of network connectivity. Of 50 biochemical pathways and 450 polar and lipid metabolites examined, the developmental regulation of the purine network was most changed. Purine network hub analysis revealed a 17-fold reversal in typ

SUBMITTER: Lingampelly SS 

PROVIDER: S-EPMC11549098 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature