Changes in body composition in early breast cancer patients treated with aromatase inhibitors.

ABSTRACT:

Purpose

The aim of the study was to analyze the modification of total and regional body composition in early breast cancer patients treated with aromatase inhibitors (AIs).

Methods

This is a prospective, single-center, observational, longitudinal study. Four-hundred and twenty-eight patients treated with adjuvant aromatase inhibitors were enrolled at the Medical Oncology and Breast Unit of Spedali Civili Hospital in Brescia from September 2014 to June 2022. Several body composition parameters including total and regional fat and lean body mass were investigated with dual-energy X-ray absorptiometry (DXA) scan at baseline and after 18 months of treatment with aromatase inhibitors.

Results

A significant increase in fat body mass (mean + 7.2%, 95% confidence interval [CI

SUBMITTER: Pedersini R 

PROVIDER: S-EPMC11549134 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature