Comparison of Vancomycin AUC24 Calculation Methods for Neonates and Infants.

ABSTRACT:

Background and objective

For neonates and infants receiving intermittent vancomycin infusions, the area under the concentration-time curve during 24 h (AUC24) is often estimated with Bayesian forecasting using one or more measured vancomycin concentrations. When practical peak and trough concentrations are measured at steady state, AUC24 can also be calculated with first-order steady-state equations for a one-compartment model (Sawchuk-Zaske method), but previously this method has been applied only for adults. The objective of this study was to compare AUC24 values obtained with the Sawchuk-Zaske method and two Bayesian models.

Methods

AUC24 values were estimated retrospectively for 18 neonates and infants with steady-state peak and trough concentrations using traditional co

SUBMITTER: Laitila T 

PROVIDER: S-EPMC11549144 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature