Racial and Sex Differences in Genomic Profiling of Intrahepatic Cholangiocarcinoma.

ABSTRACT:

Background

Racial and sex disparities in the incidence and outcomes of patients with intrahepatic cholangiocarcinoma (iCCA) exist, yet potential genomic variations of iCCA based on race and sex that might be contributing to disparate outcomes have not been well studied.

Methods

Data from the American Association for Cancer Research Project GENIE registry (version 15.0) were analyzed to assess genetic variations in iCCA. Adult patients (age >18 years) with histologically confirmed iCCA who underwent next-generation sequencing were included in the analytic cohort. Racial and sex variations in genomic profiling of iCCA were examined.

Results

The study enrolled 1068 patients from 19 centers (White, 71.9%; Black, 5.1%; Asian, 8.4%, other, 14.6%). The male-to-female ratio w

SUBMITTER: Tsilimigras DI 

PROVIDER: S-EPMC11549159 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature