Behavioral and neurophysiological signatures of cognitive control in humans and rats.

ABSTRACT:

Background

Deficits in cognitive control are implicated in numerous neuropsychiatric disorders. However, relevant pharmacological treatments are limited, likely due to weak translational validity of applicable preclinical models used. Neural indices derived from electroencephalography may prove useful in comparing and translating the effects of cognition-enhancing drugs between species. In the current study, we aimed to extend our previous cross-species results by examining if methylphenidate (MPH) modulates behavioral and neural indices of cognitive control in independent cohorts of humans and rats.

Methods

We measured continuous electroencephalography data from healthy adults (n = 25; 14 female) and Long Evans rats (n = 22; 8 female) and compared both stimulus- and respons

SUBMITTER: Linton SR 

PROVIDER: S-EPMC11549206 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature