Comparative analysis of the postadmission and antemortem oropharyngeal and rectal swab microbiota of ICU patients.

ABSTRACT: Shotgun metabarcoding was conducted to examine the microbiota in a total of 48 samples from 12 critically ill patients, analyzing samples from both the oropharynx and rectum. We aimed to compare their postadmission microbiota, characterized as moderately dysbiotic, with the severely dysbiotic antemortem microbiota associated with patients' deaths. We found that, compared with postadmission samples, patient antemortem swab samples presented moderate but not significantly decreased diversity indices. The antemortem oropharyngeal samples presented an increase in biofilm-forming bacteria, including Streptococcus oralis, methicillin-resistant Staphylococcus aureus (MRSA), and Enterococcus faecalis. Although the septic shock rate was 67%, no significant differences were detected in the potential

SUBMITTER: Petrilla A 

PROVIDER: S-EPMC11549221 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature