Material decomposition approaches for monosodium urate (MSU) quantification in gouty arthritis: a (bio)phantom study.

ABSTRACT:

Background

Dual-energy computed tomography (DECT) is a noninvasive diagnostic tool for gouty arthritis. This study aimed to compare two postprocessing techniques for monosodium urate (MSU) detection: conventional two-material decomposition and material map-based decomposition.

Methods

A raster phantom and an ex vivo biophantom, embedded with four different MSU concentrations, were scanned in two high-end CT scanners. Scanner 1 used the conventional postprocessing method while scanner 2 employed the material map approach. Volumetric analysis was performed to determine MSU detection, and image quality parameters, such as signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), were computed.

Results

The material map-based method demonstrated superior MSU detection

SUBMITTER: Diekhoff T 

PROVIDER: S-EPMC11549270 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature