Murine colon cancer derived cells exhibit heterogeneous resistance profiles against an oncolytic virus.

ABSTRACT: Oncolytic virotherapy has shown efficacy in various animal models and a few human cancers. However, there are still significant limitations for the implementation of these therapies. One such limitation is the emergence of cellular resistances, which may appear rapidly considering the high genetic heterogeneity of most tumors. We previously showed that cellular resistance to an oncolytic virus can be mediated by the chronic activation of innate immunity. Here, we explored the existence of additional resistance mechanisms in murine colon cancer-derived cells. For this purpose, we isolated two cellular clones that were resistant to the oncolytic virus VSV-D51. While one of the clones showed a strong resistance profile associated with increased cytokine-mediated antiviral responses, the other

SUBMITTER: Larrieux A 

PROVIDER: S-EPMC11549347 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature